Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.69 |
| ▸ | ATM | Q13315 | 1/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | PDE9A | O76083 | 14/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.47 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.47 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.47 |
| ▸ | DAPK2 | Q9UIK4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19342087 | 0.86 | DAPK3 (0.61) | MEN1KMT2AATMCYP1A2CYP3A4 | |
| SCHEMBL19342123 | 0.81 | MEN1 (1.00) | MEN1KMT2AATMCYP1A2CYP3A4 | |
| SCHEMBL19342095 | 0.80 | CYP1A2 (0.83) | MEN1KMT2AATMCYP1A2CYP3A4 | |
| SCHEMBL19342107 | 0.80 | CYP1A2 (0.83) | MEN1KMT2AATMCYP1A2CYP3A4 | |
| SCHEMBL19342100 | 0.79 | MEN1 (0.77) | MEN1KMT2AATMCYP1A2CYP3A4 | |
| SCHEMBL19342106 | 0.78 | MEN1 (0.75) | MEN1KMT2AATMCYP1A2CYP3A4 | |
| SCHEMBL19342108 | 0.78 | CYP1A2 (0.79) | MEN1KMT2AATMCYP1A2CYP3A4 | |
| SCHEMBL19342104 | 0.78 | MEN1 (0.80) | MEN1KMT2AATMCYP1A2CYP3A4 | |
| SCHEMBL19342113 | 0.78 | MEN1 (0.80) | MEN1KMT2AATMCYP1A2CYP3A4 | |
| SCHEMBL19327570 | 0.78 | MEN1 (0.80) | MEN1KMT2AATMCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210155627-A1 | KINASE INHIBITORS AND RELATED METHODS OF USE | UTI LIMITED PARTNERSHIP (CA) | 2021-05-27 | — | — | US | disclosed |
| US-10934291-B2 | Kinase inhibitors and related methods of use | DUKE UNIVERSITY (US) | 2021-03-02 | — | — | US | disclosed |
| US-20170260191-A1 | KINASE INHIBITORS AND RELATED METHODS OF USE | DUKE UNIVERSITY | 2017-09-14 | — | — | US | disclosed |
| US-20170260191-A1 | KINASE INHIBITORS AND RELATED METHODS OF USE | DUKE UNIVERSITY | 2017-09-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10934291-B2 | Kinase inhibitors and related methods of use | DAPK2, DAPK1, DAPK3 | MEN1 4284/4885KMT2A 2109/4885ATM 167/4885 |
| US-20170260191-A1 | KINASE INHIBITORS AND RELATED METHODS OF USE | DAPK2, DAPK1, DAPK3 | MEN1 4284/4885KMT2A 2109/4885ATM 167/4885 |
| US-20210155627-A1 | KINASE INHIBITORS AND RELATED METHODS OF USE | DAPK2, DAPK1, DAPK3 | MEN1 4284/4885KMT2A 2109/4885ATM 167/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.