Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 19/20 | 0.82 |
| ▸ | OPRM1 | P35372 | 17/20 | 0.82 |
| ▸ | OPRK1 | P41145 | 17/20 | 0.82 |
| ▸ | OPRD1 | P41143 | 16/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8080155 | 0.85 | OPRL1 (0.64) | OPRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL19343291 | 0.82 | OPRL1 (0.57) | OPRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL15463710 | 0.81 | OPRL1 (0.62) | OPRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL7696081 | 0.78 | OPRL1 (0.73) | OPRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL19343455 | 0.78 | OPRL1 (0.59) | OPRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL8601661 | 0.77 | CYP2D6 (0.84) | OPRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL7330238 | 0.77 | CYP2D6 (0.84) | OPRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL7330243 | 0.77 | CYP2D6 (0.84) | OPRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL10819303 | 0.77 | CYP2D6 (0.60) | OPRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL28219815 | 0.77 | CYP2D6 (0.60) | OPRL1OPRM1OPRK1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3884939-B1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS INC (US) | 2023-10-25 | — | — | EP | disclosed |
| EP-3884939-A1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | Raze Therapeutics, Inc. (US) | 2021-09-29 | — | — | EP | disclosed |
| EP-3426243-B1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS INC (US) | 2021-05-19 | — | — | EP | disclosed |
| WO-2017156165-A1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2017-09-14 | — | — | WO | disclosed |