Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.84 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.84 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.84 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.84 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.84 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.84 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.84 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.84 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.84 |
| ▸ | OPRL1 | P41146 | 12/20 | 0.70 |
| ▸ | OPRM1 | P35372 | 10/20 | 0.70 |
| ▸ | OPRD1 | P41143 | 10/20 | 0.70 |
| ▸ | OPRK1 | P41145 | 10/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7330238 | 1.00 | CYP2D6 (0.84) | CYP2D6GRIN2DGRIN3BGRIN1KCNH2 | |
| SCHEMBL8601661 | 1.00 | CYP2D6 (0.84) | CYP2D6GRIN2DGRIN3BGRIN1KCNH2 | |
| Traxoprodil SCHEMBL8337144 | 0.92 | GRIN2B (1.00) | CYP2D6GRIN2DGRIN3BGRIN1KCNH2 | |
| Traxoprodil SCHEMBL5888841 | 0.92 | GRIN2B (1.00) | CYP2D6GRIN2DGRIN3BGRIN1KCNH2 | |
| Traxoprodil SCHEMBL4248 | 0.92 | GRIN2B (1.00) | CYP2D6GRIN2DGRIN3BGRIN1KCNH2 | |
| Traxoprodil SCHEMBL6702711 | 0.92 | GRIN2B (1.00) | CYP2D6GRIN2DGRIN3BGRIN1KCNH2 | |
| Traxoprodil SCHEMBL6800343 | 0.92 | GRIN2B (1.00) | CYP2D6GRIN2DGRIN3BGRIN1KCNH2 | |
| SCHEMBL8497418 | 0.92 | KCNH2 (0.81) | CYP2D6GRIN2DGRIN3BGRIN1KCNH2 | |
| Traxoprodil SCHEMBL5517640 | 0.92 | GRIN2B (1.00) | CYP2D6GRIN2DGRIN3BGRIN1KCNH2 | |
| SCHEMBL7337251 | 0.90 | KCNH2 (0.79) | CYP2D6GRIN2DGRIN3BGRIN1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5527912-A | USEFUL INTREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | PFIZER INC. (US) | 1996-06-18 | — | — | US | disclosed |
| US-5391742-A | Intermediates for 2-piperidino-1-alkanols | PFIZER INC. (US) | 1995-02-21 | — | — | US | disclosed |
| US-5338754-A | 2-pyrrolidino-1-alkanol derivatives as antiischemic agents | PFIZER INC (US) | 1994-08-16 | — | — | US | disclosed |
| US-5272160-A | 2-piperidino-1-alkanol derivatives as antiischemic agents | PFIZER INC (US) | 1993-12-21 | — | — | US | disclosed |
| US-5185343-A | NORTROPYL-1-ALKANOL DERIVATIVES AS ANTIISCHEMIC AGENTS | PFIZER INC. (US) | 1993-02-09 | — | — | US | disclosed |
| WO-1990014088-A1 | 2-PIPERIDINO-1-ALKANOL DERIVATIVES AS ANTIISCHEMIC AGENTS | PFIZER INC. (US) | 1990-11-29 | — | — | WO | disclosed |