⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18571918 | 0.83 | PRMT5 (0.42) | — | |
| SCHEMBL19344400 | 0.80 | PI4KA (0.47) | — | |
| SCHEMBL19343822 | 0.78 | NT5E (0.32) | — | |
| SCHEMBL18571698 | 0.77 | PRMT5 (0.38) | — | |
| SCHEMBL19343922 | 0.77 | RXFP1 (0.34) | — | |
| SCHEMBL21130079 | 0.77 | — | — | |
| SCHEMBL18026278 | 0.75 | PRMT5 (0.44) | — | |
| SCHEMBL18009743 | 0.75 | PRMT5 (0.44) | — | |
| SCHEMBL13664036 | 0.75 | — | — | |
| SCHEMBL23584458 | 0.74 | NT5E (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426664-B1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-30 | — | — | EP | disclosed |
| US-20200289539-A1 | NOVEL SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-09-17 | — | — | US | disclosed |
| WO-2017153186-A1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-09-14 | — | — | WO | disclosed |