Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NT5E | P21589 | 2/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 17/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 16/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19343806 | 1.00 | NT5E (0.39) | NT5EPRMT5WDR77RXFP1 | |
| SCHEMBL19343822 | 0.89 | NT5E (0.32) | NT5EPRMT5WDR77 | |
| SCHEMBL18571698 | 0.82 | PRMT5 (0.38) | PRMT5WDR77 | |
| SCHEMBL18571690 | 0.81 | PI4KA (0.53) | NT5EPRMT5WDR77RXFP1 | |
| SCHEMBL18571918 | 0.79 | PRMT5 (0.42) | PRMT5WDR77 | |
| SCHEMBL31526212 | 0.78 | NT5E (0.44) | NT5EPRMT5WDR77RXFP1 | |
| SCHEMBL31570716 | 0.77 | NT5E (0.42) | NT5EPRMT5WDR77RXFP1 | |
| SCHEMBL18009743 | 0.75 | PRMT5 (0.44) | PRMT5WDR77 | |
| SCHEMBL18026278 | 0.75 | PRMT5 (0.44) | PRMT5WDR77 | |
| SCHEMBL19343872 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426664-B1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-30 | — | — | EP | disclosed |