Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22434948 | 1.00 | PRMT5 (0.35) | PRMT5KCNH2OPRM1SIGMAR1GRIN2B | |
| SCHEMBL19344255 | 0.90 | OPRM1 (0.32) | KCNH2OPRM1SIGMAR1 | |
| SCHEMBL22435030 | 0.90 | PRMT5 (0.37) | PRMT5KCNH2OPRM1SIGMAR1 | |
| SCHEMBL19343975 | 0.90 | PRMT5 (0.37) | PRMT5KCNH2OPRM1SIGMAR1 | |
| SCHEMBL22434992 | 0.89 | PRMT5 (0.37) | PRMT5 | |
| SCHEMBL22434945 | 0.89 | PRMT5 (0.38) | PRMT5 | |
| SCHEMBL19344190 | 0.87 | PRMT5 (0.44) | PRMT5KCNH2OPRM1SIGMAR1GRIN2B | |
| SCHEMBL19344144 | 0.87 | PRMT5 (0.36) | PRMT5 | |
| SCHEMBL19343984 | 0.86 | PRMT5 (0.36) | PRMT5 | |
| SCHEMBL19344145 | 0.85 | PRMT5 (0.48) | PRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017153186-A1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-09-14 | — | — | WO | disclosed |