Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 2/20 | 0.43 |
| ▸ | SRC | P12931 | 17/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23584818 | 1.00 | PRMT5 (0.43) | PRMT5SRCEGFRGPR119 | |
| SCHEMBL23584524 | 0.90 | PRMT5 (0.47) | PRMT5 | |
| SCHEMBL19344024 | 0.89 | PRMT5 (0.44) | PRMT5SRCEGFR | |
| SCHEMBL19344006 | 0.89 | PRMT5 (0.48) | PRMT5SRCEGFRGPR119 | |
| SCHEMBL23584856 | 0.87 | PRMT5 (0.57) | PRMT5SRC | |
| SCHEMBL23584786 | 0.84 | PRMT5 (0.47) | PRMT5SRCEGFRGPR119 | |
| SCHEMBL19344004 | 0.84 | PRMT5 (0.49) | PRMT5 | |
| SCHEMBL19344268 | 0.81 | PRMT5 (0.45) | PRMT5SRCEGFRGPR119 | |
| SCHEMBL23584613 | 0.80 | PRMT5 (0.50) | PRMT5SRCEGFRGPR119 | |
| SCHEMBL22435021 | 0.80 | PRMT5 (0.35) | PRMT5SRCEGFRGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017153186-A1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-09-14 | — | — | WO | disclosed |