Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 13/20 | 0.47 |
| ▸ | WDR77 | Q9BQA1 | 6/20 | 0.43 |
| ▸ | IGF1R | P08069 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ACACB | O00763 | 1/20 | 0.31 |
| ▸ | METTL3 | Q86U44 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23584856 | 0.91 | PRMT5 (0.57) | PRMT5WDR77MEN1ACACBMETTL3 | |
| SCHEMBL23584818 | 0.90 | PRMT5 (0.43) | PRMT5 | |
| SCHEMBL19344039 | 0.90 | PRMT5 (0.43) | PRMT5 | |
| SCHEMBL23584724 | 0.89 | PRMT5 (0.36) | PRMT5WDR77ACACB | |
| SCHEMBL19343956 | 0.89 | PRMT5 (0.36) | PRMT5WDR77ACACB | |
| SCHEMBL22434834 | 0.88 | PRMT5 (0.48) | PRMT5WDR77METTL3 | |
| SCHEMBL19344231 | 0.83 | PRMT5 (0.59) | PRMT5WDR77METTL3 | |
| SCHEMBL19344313 | 0.79 | PRMT5 (0.59) | PRMT5WDR77METTL3 | |
| SCHEMBL19344617 | 0.79 | PRMT5 (0.56) | PRMT5WDR77METTL3 | |
| SCHEMBL22434835 | 0.79 | PRMT5 (0.51) | PRMT5WDR77MEN1METTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426664-B1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-30 | — | — | EP | disclosed |