Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 7/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 6/20 | 0.37 |
| ▸ | NNMT | P40261 | 12/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20049423 | 1.00 | PRMT5 (0.37) | PRMT5WDR77NNMTFGFR1FGFR4 | |
| SCHEMBL21312848 | 0.89 | PRMT5 (0.33) | PRMT5WDR77NNMTFGFR1FGFR4 | |
| SCHEMBL21312896 | 0.80 | PRMT5 (0.36) | PRMT5WDR77NNMTFGFR1FGFR4 | |
| SCHEMBL22685145 | 0.79 | NNMT (0.34) | PRMT5WDR77NNMT | |
| SCHEMBL22002065 | 0.78 | NNMT (0.36) | PRMT5WDR77NNMT | |
| SCHEMBL24067745 | 0.78 | NNMT (0.38) | PRMT5WDR77NNMT | |
| SCHEMBL24090740 | 0.77 | PRMT5 (0.40) | PRMT5WDR77NNMT | |
| SCHEMBL25049137 | 0.76 | NNMT (0.36) | PRMT5WDR77NNMT | |
| SCHEMBL24067669 | 0.76 | PRMT5 (0.34) | PRMT5WDR77NNMT | |
| SCHEMBL21312931 | 0.75 | PRMT5 (0.40) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017153186-A1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-09-14 | — | — | WO | disclosed |