Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 3/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.39 |
| ▸ | CNR2 | P34972 | 3/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.35 |
| ▸ | NAMPT | P43490 | 4/20 | 0.34 |
| ▸ | CNR1 | P21554 | 2/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19344042 | 0.88 | PRMT5 (0.49) | PRMT5WDR77 | |
| SCHEMBL19343917 | 0.86 | PRMT5 (0.53) | PRMT5WDR77CNR2GPR119 | |
| SCHEMBL19343827 | 0.86 | PRMT5 (0.53) | PRMT5WDR77CNR2GPR119 | |
| SCHEMBL19344407 | 0.86 | PRMT5 (0.43) | PRMT5WDR77CNR2GPR119NAMPT | |
| SCHEMBL23584770 | 0.86 | PRMT5 (0.43) | PRMT5WDR77CNR2GPR119NAMPT | |
| SCHEMBL23584690 | 0.86 | PRMT5 (0.52) | PRMT5WDR77CNR2GPR119 | |
| SCHEMBL23584761 | 0.84 | PRMT5 (0.41) | PRMT5WDR77CNR2ADORA1GPR119 | |
| SCHEMBL23584726 | 0.84 | PRMT5 (0.50) | PRMT5WDR77GPR119 | |
| SCHEMBL19344203 | 0.84 | PRMT5 (0.44) | PRMT5WDR77CNR2ADORA1GPR119 | |
| SCHEMBL23584467 | 0.82 | PRMT5 (0.47) | PRMT5WDR77GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426664-B1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-30 | — | — | EP | disclosed |
| WO-2017153186-A1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-09-14 | — | — | WO | disclosed |