Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 3/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | NAMPT | P43490 | 7/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23584770 | 0.99 | PRMT5 (0.43) | PRMT5WDR77GPR119CNR2NAMPT | |
| SCHEMBL23584761 | 0.98 | PRMT5 (0.41) | PRMT5WDR77GPR119CNR2NAMPT | |
| SCHEMBL23584660 | 0.96 | GPR119 (0.39) | PRMT5WDR77GPR119CNR2NAMPT | |
| SCHEMBL23584763 | 0.94 | PRMT5 (0.40) | PRMT5WDR77GPR119CNR2NAMPT | |
| SCHEMBL19343827 | 0.91 | PRMT5 (0.53) | PRMT5WDR77GPR119CNR2 | |
| SCHEMBL19343917 | 0.91 | PRMT5 (0.53) | PRMT5WDR77GPR119CNR2 | |
| SCHEMBL19344038 | 0.90 | GPR119 (0.36) | PRMT5WDR77GPR119NAMPTOPRD1 | |
| SCHEMBL23584690 | 0.90 | PRMT5 (0.52) | PRMT5WDR77GPR119CNR2 | |
| SCHEMBL23584726 | 0.89 | PRMT5 (0.50) | PRMT5WDR77GPR119 | |
| SCHEMBL23584704 | 0.88 | GPR119 (0.34) | PRMT5WDR77GPR119NAMPTOPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426664-B1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-30 | — | — | EP | disclosed |
| WO-2017153186-A1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-09-14 | — | — | WO | disclosed |