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Sugi Predict / Compounds / SCHEMBL19344273

SCHEMBL19344273

SCHEMBL19344273

C=C[C@@H]1[C@@H](CN2CC(F)(F)CC23CCN(C(=O)OC(C)(C)C)CC3)C[C@@H](n2ccc3c(N)ncnc32)[C@@H]1OC(C)(C)O

nearest known ligand 0.42

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ PRMT5 O14744 9/20 0.42
▸ WDR77 Q9BQA1 3/20 0.35
▸ SRC P12931 10/20 0.33
▸ EGFR P00533 1/20 0.33
▸ GPR119 Q8TDV5 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19344004 0.86 PRMT5 (0.49) PRMT5WDR77
SCHEMBL19344024 0.85 PRMT5 (0.44) PRMT5WDR77SRCEGFR
SCHEMBL19344268 0.83 PRMT5 (0.45) PRMT5WDR77SRCEGFRGPR119
SCHEMBL19344006 0.82 PRMT5 (0.48) PRMT5WDR77SRCEGFRGPR119
SCHEMBL23584786 0.80 PRMT5 (0.47) PRMT5WDR77SRCEGFRGPR119
SCHEMBL23584818 0.79 PRMT5 (0.43) PRMT5SRCEGFRGPR119
SCHEMBL19344039 0.79 PRMT5 (0.43) PRMT5SRCEGFRGPR119
SCHEMBL23584613 0.79 PRMT5 (0.50) PRMT5WDR77SRCEGFRGPR119
SCHEMBL19343960 0.76 PRMT5 (0.35) PRMT5SRCEGFRGPR119
SCHEMBL22435021 0.76 PRMT5 (0.35) PRMT5SRCEGFRGPR119

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3426664-B1 SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2021-06-30 — — EP disclosed
WO-2017153186-A1 SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2017-09-14 — — WO disclosed
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