Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDE | P14735 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | APEX1 | P27695 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19332443 | 0.90 | TDP1 (0.56) | ALDH1A1TDP1POLBL3MBTL1APEX1 | |
| SCHEMBL19332597 | 0.90 | MAPT (0.54) | ALDH1A1TDP1POLBL3MBTL1APEX1 | |
| SCHEMBL19346220 | 0.85 | MAPT (0.56) | ALDH1A1TDP1POLBL3MBTL1APEX1 | |
| SCHEMBL19345893 | 0.84 | L3MBTL1 (0.50) | ALDH1A1TDP1POLBL3MBTL1APEX1 | |
| SCHEMBL19332587 | 0.84 | L3MBTL1 (0.50) | ALDH1A1TDP1POLBL3MBTL1APEX1 | |
| SCHEMBL17593216 | 0.82 | L3MBTL1 (0.57) | ALDH1A1TDP1POLBL3MBTL1KMT2A | |
| SCHEMBL19332346 | 0.82 | L3MBTL1 (0.52) | ALDH1A1TDP1POLBL3MBTL1KMT2A | |
| SCHEMBL19332549 | 0.82 | KMT2A (0.52) | ALDH1A1TDP1POLBL3MBTL1KMT2A | |
| SCHEMBL19332216 | 0.82 | MAPT (0.57) | ALDH1A1TDP1POLBL3MBTL1KMT2A | |
| SCHEMBL19332444 | 0.81 | TDP1 (0.58) | ALDH1A1TDP1POLBL3MBTL1APEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017156181-A1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2017-09-14 | — | — | WO | disclosed |