Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 2/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | LCK | P06239 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1934745 | 1.00 | MCL1 (0.39) | MCL1RPS6KA3JAK3KDM4EMAPT | |
| SCHEMBL15804824 | 0.79 | EGFR (0.42) | MCL1RPS6KA3JAK3KDM4EMAPT | |
| SCHEMBL15804809 | 0.79 | EGFR (0.42) | MCL1RPS6KA3JAK3KDM4EMAPT | |
| SCHEMBL8720918 | 0.76 | — | — | |
| SCHEMBL22501797 | 0.75 | EGFR (0.46) | KDM4EMAPTMEN1KMT2APOLB | |
| SCHEMBL3711696 | 0.74 | — | — | |
| SCHEMBL27703040 | 0.74 | — | — | |
| SCHEMBL7523076 | 0.71 | MCL1 (0.43) | MCL1RPS6KA3JAK3KDM4EMAPT | |
| SCHEMBL28312635 | 0.69 | EGFR (0.41) | MCL1RPS6KA3JAK3KDM4EMAPT | |
| SCHEMBL10500196 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2506852-A2 | INTERFERON THERAPIES IN COMBINATION WITH BLOCKADE OF STAT3 ACTIVATION | Board Of Regents, The University Of Texas System (US) | 2012-10-10 | — | — | EP | disclosed |
| WO-2011069141-A2 | INTERFERON THERAPIES IN COMBINATION WITH BLOCKADE OF STAT3 ACTIVATION | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2011-06-09 | — | — | WO | disclosed |