Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.57 |
| ▸ | NPC1 | O15118 | 5/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30593991 | 1.00 | RAB9A (0.57) | RAB9ANPC1KMT2AKDM4ETSHR | |
| SCHEMBL5381046 | 0.84 | KDM4E (0.69) | RAB9ANPC1KMT2AKDM4EMAPT | |
| SCHEMBL20767994 | 0.81 | RAB9A (0.49) | RAB9ANPC1KMT2AKDM4ETSHR | |
| SCHEMBL4208169 | 0.81 | KMT2A (0.54) | RAB9ANPC1KMT2AKDM4ETSHR | |
| SCHEMBL4237518 | 0.81 | RAB9A (0.56) | RAB9ANPC1KMT2AKDM4ETSHR | |
| SCHEMBL25097159 | 0.81 | KMT2A (0.54) | RAB9ANPC1KMT2AKDM4ETSHR | |
| SCHEMBL4692505 | 0.81 | KMT2A (0.54) | RAB9ANPC1KMT2AKDM4ETSHR | |
| SCHEMBL5139472 | 0.81 | KMT2A (0.54) | RAB9ANPC1KMT2AKDM4ETSHR | |
| SCHEMBL9131695 | 0.79 | KDM4E (0.46) | RAB9ANPC1KMT2AKDM4ETSHR | |
| SCHEMBL22950992 | 0.78 | RAB9A (0.61) | RAB9ANPC1KMT2AKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3983072-A1 | PYRAZINE CARBAMATES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | Janssen Pharmaceutica NV (BE) | 2022-04-20 | — | — | EP | disclosed |
| CN-113874074-A | HMOX1 inducers | 米托布里奇公司 | 2021-12-31 | — | — | CN | disclosed |
| CN-109641915-A | Novel 4- (aryl)-N- (3- alkoxy furans simultaneously [2,3-B] pyrazine -2- base)-piperazine -1- carboxamides derivatives and its antiproliferative effect | 东国大学校产学协力团 | 2019-04-16 | — | — | CN | disclosed |
| CN-105358151-B | For treating the compound of Duchenne-Arandisease | 豪夫迈·罗氏有限公司 | 2019-04-12 | — | — | CN | disclosed |
| CN-108774237-A | New tricyclic compound | ABBVIE 公司 | 2018-11-09 | — | — | CN | disclosed |
| CN-104370909-B | Tricyclic compound | ABBVIE 公司 | 2018-09-11 | — | — | CN | disclosed |
| CN-105358151-A | Compounds for treating spinal muscular atrophy | HOFFMANN LA ROCHE | 2016-02-24 | — | — | CN | disclosed |
| CN-102264721-B | Compounds useful as inhibitors of ATR kinase | VERTEX PHARMACEUTICALS INC. (US) | 2015-12-09 | — | — | CN | disclosed |
| CN-104370909-A | Novel tricyclic compounds | ABBOTT LAB | 2015-02-25 | — | — | CN | disclosed |
| CN-102264721-A | Compounds useful as inhibitors of ATR kinase | — | 2011-11-30 | — | — | CN | disclosed |
| WO-2011068881-A1 | NOVEL TRICYCLIC COMPOUNDS | ABBOTT LABORATORIES (US) | 2011-06-09 | — | — | WO | disclosed |
| CN-1407973-A | Butynediol Derivatives | ACTELION PHARMACEUTICALS LTD (CH) | 2003-04-02 | — | — | CN | disclosed |
| EP-0508469-B1 | 3,4,N-Trisubstituted-4,5-dihydro-1H-pyrazole-1-carboxamides and their use as insecticides | DOWELANCO (US) | 1999-03-03 | — | — | EP | disclosed |
| US-5493024-A | 1,2-DIARYL-2-PROPEN-1-ONE CHEMICAL INTERMEDIATE COMPOUND | DOWELANCO (US) | 1996-02-20 | — | — | US | disclosed |
| US-5250532-A | Moths. termites | DOWELANCO (US) | 1993-10-05 | — | — | US | disclosed |
| CN-1067426-A | 3,4, N-three replaces-4,5-dihydro-1 h-pyrazole-1-methane amide and they application as sterilant | DOWELANCO (US) | 1992-12-30 | — | — | CN | disclosed |
| EP-0508469-A1 | 3,4,N-Trisubstituted-4,5-dihydro-1H-pyrazole-1-carboxamides and their use as insecticides | DOWELANCO (US) | 1992-10-14 | — | — | EP | disclosed |