SCHEMBL19348111

SCHEMBL19348111

COc1ccccc1[C@H](Cn1c(=O)n(C(C)(C)C(=O)OCc2ccccc2)c(=O)c2c(C)c(Br)sc21)OC1CCOCC1

nearest known ligand 0.83

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ACACB O00763 11/20 0.83
ACACA Q13085 14/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28349988 0.91 ACACB (1.00) ACACBACACA
SCHEMBL28349987 0.91 ACACB (1.00) ACACBACACA
SCHEMBL22144554 0.90 ACACB (1.00) ACACBACACA
SCHEMBL21905394 0.90 ACACB (1.00) ACACBACACA
SCHEMBL18909873 0.90 ACACB (0.67) ACACBACACA
SCHEMBL19369286 0.90 ACACB (0.81) ACACBACACA
SCHEMBL14945396 0.87 ACACB (0.80) ACACBACACA
SCHEMBL30130074 0.87 ACACB (0.80) ACACBACACA
SCHEMBL19361566 0.87 ACACA (0.84) ACACBACACA
SCHEMBL28403880 0.86 ACACB (0.85) ACACBACACA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11912718-B2 Solid forms of a thienopyrimidinedione ACC inhibitor and methods for production thereof GILEAD APOLLO, LLC (US) 2024-02-27 US disclosed
US-11912718-B2 Solid forms of a thienopyrimidinedione ACC inhibitor and methods for production thereof GILEAD APOLLO, LLC (US) 2024-02-27 US disclosed
US-11912718-B2 Solid forms of a thienopyrimidinedione ACC inhibitor and methods for production thereof GILEAD APOLLO, LLC (US) 2024-02-27 US disclosed
EP-3423456-B1 SOLID FORMS OF A THIENOPYRIMIDINEDIONE ACC INHIBITOR AND METHODS FOR PRODUCTION THEREOF GILEAD APOLLO LLC (US) 2023-12-27 EP disclosed
US-20220064181-A1 SOLID FORMS OF A THIENOPYRIMIDINEDIONE ACC INHIBITOR AND METHODS FOR PRODUCTION THEREOF GILEAD APOLLO, LLC 2022-03-03 US disclosed
US-20200148699-A1 SOLID FORMS OF A THIENOPYRIMIDINEDIONE ACC INHIBITOR AND METHODS FOR PRODUCTION THEREOF GILEAD APOLLO, LLC 2020-05-14 US disclosed
US-20190225623-A1 SOLID FORMS OF A THIENOPYRIMIDINEDIONE ACC INHIBITOR AND METHODS FOR PRODUCTION THEREOF NIMBUS DISCOVERY, INC. 2019-07-25 US disclosed
US-10183951-B2 Solid forms of a thienopyrimidinedione ACC inhibitor and methods for production thereof GILEAD APOLLO, LLC (US) 2019-01-22 US disclosed
US-20170267690-A1 SOLID FORMS OF A THIENOPYRIMIDINEDIONE ACC INHIBITOR AND METHODS FOR PRODUCTION THEREOF J.P. LAWSON CONSULTING LLC 2017-09-21 US disclosed
US-20170267690-A1 SOLID FORMS OF A THIENOPYRIMIDINEDIONE ACC INHIBITOR AND METHODS FOR PRODUCTION THEREOF J.P. LAWSON CONSULTING LLC 2017-09-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170267690-A1 SOLID FORMS OF A THIENOPYRIMIDINEDIONE ACC INHIBITOR AND METHODS FOR PRODUCTION THEREOF ACACA, ACACB, COASY ACACB 2/4885ACACA 1/4885
US-11912718-B2 Solid forms of a thienopyrimidinedione ACC inhibitor and methods for production thereof ACACA, ACACB, COASY ACACB 2/4885ACACA 1/4885
US-20200148699-A1 SOLID FORMS OF A THIENOPYRIMIDINEDIONE ACC INHIBITOR AND METHODS FOR PRODUCTION THEREOF ACACA, ACACB, COASY ACACB 2/4885ACACA 1/4885
US-20220064181-A1 SOLID FORMS OF A THIENOPYRIMIDINEDIONE ACC INHIBITOR AND METHODS FOR PRODUCTION THEREOF ACACA, ACACB, COASY ACACB 2/4885ACACA 1/4885
US-10183951-B2 Solid forms of a thienopyrimidinedione ACC inhibitor and methods for production thereof ACACA, ACACB, COASY ACACB 2/4885ACACA 1/4885
US-20190225623-A1 SOLID FORMS OF A THIENOPYRIMIDINEDIONE ACC INHIBITOR AND METHODS FOR PRODUCTION THEREOF ACACA, ACACB, COASY ACACB 2/4885ACACA 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.