SCHEMBL1935003

SCHEMBL1935003

CN(C(=O)c1cnn2ccc(-c3cccc(C(=O)NC4(c5ccccc5)CC4)c3)cc12)c1ccc(F)cc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EPHB3 P54753 2/20 0.40
ADCY8 P40145 1/20 0.36
ADCY1 Q08828 1/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2C8 P10632 1/20 0.36
DGAT2 Q96PD7 1/20 0.36
TGFBR1 P36897 1/20 0.35
DYRK1A Q13627 2/20 0.34
TTK P33981 1/20 0.34
MAST3 O60307 2/20 0.34
MAPK8 P45983 2/20 0.34
ITK Q08881 1/20 0.34
GPBAR1 Q8TDU6 1/20 0.34
CNR2 P34972 2/20 0.34
ROCK2 O75116 1/20 0.34
ROCK1 Q13464 1/20 0.34
CNR1 P21554 1/20 0.34
JAK1 P23458 1/20 0.34
JAK3 P52333 1/20 0.34
KDM4E B2RXH2 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1934827 0.86 CYP2C8 (0.48) EPHB3CYP3A4CYP2C8TGFBR1MAPK8
SCHEMBL1936906 0.76 NPC1 (0.42) EPHB3CYP3A4CYP2C8MAST3MAPK8
SCHEMBL1935004 0.75 CYP2C8 (0.48) ADCY8ADCY1CYP3A4CYP2C8DGAT2
SCHEMBL2467410 0.72 CYP2C8 (0.46) CYP3A4CYP2C8DGAT2MAPK8ROCK2
SCHEMBL1936957 0.70 EPHB3 (0.41) EPHB3CYP3A4CYP2C8DGAT2TGFBR1
SCHEMBL1937044 0.66 CYP2C8 (0.52) ADCY8ADCY1CYP3A4CYP2C8DYRK1A
SCHEMBL1937087 0.65 CYP2C8 (0.44) CYP3A4CYP2C8DGAT2TTK
SCHEMBL13266234 0.65 CYP3A4 (0.41) ADCY8ADCY1CYP3A4CYP2C8TTK
SCHEMBL1936590 0.65 CYP3A4 (0.44) ADCY8ADCY1CYP3A4CYP2C8ROCK2
SCHEMBL9911902 0.65 CYP2C8 (0.62) CYP3A4CYP2C8DGAT2CNR2ROCK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2331502-A2 COMPOUNDS FOR THE TREATMENT OF HEPATITIS C Bristol-Myers Squibb Company (US) 2011-06-15 EP disclosed