Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.56 |
| ▸ | BACE2 | Q9Y5Z0 | 4/20 | 0.53 |
| ▸ | CTSD | P07339 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1935330 | 1.00 | BACE1 (0.56) | BACE1BACE2CTSD | |
| SCHEMBL1935189 | 0.91 | BACE1 (0.52) | BACE1BACE2CTSD | |
| SCHEMBL1935714 | 0.91 | BACE1 (0.54) | BACE1BACE2CTSD | |
| SCHEMBL2108596 | 0.88 | BACE1 (0.41) | BACE1BACE2 | |
| SCHEMBL2344107 | 0.88 | BACE1 (0.52) | BACE1BACE2CTSD | |
| SCHEMBL2108425 | 0.86 | BACE1 (0.39) | BACE1BACE2 | |
| SCHEMBL1935227 | 0.86 | BACE1 (0.48) | BACE1BACE2CTSD | |
| SCHEMBL1935229 | 0.86 | BACE1 (0.48) | BACE1BACE2CTSD | |
| SCHEMBL1934929 | 0.85 | BACE1 (0.46) | BACE1BACE2CTSD | |
| SCHEMBL1934572 | 0.83 | BACE1 (0.46) | BACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2332943-B1 | NOVEL FUSED AMINODIHYDROTHIAZINE DERIVATIVE | EISAI R&D MAN CO LTD (JP) | 2015-04-22 | — | — | EP | disclosed |
| EP-2332943-A1 | NOVEL FUSED AMINODIHYDROTHIAZINE DERIVATIVE | Eisai R&D Management Co., Ltd. (JP) | 2011-06-15 | — | — | EP | disclosed |