Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | JAK1 | P23458 | 2/20 | 0.45 |
| ▸ | JAK3 | P52333 | 2/20 | 0.45 |
| ▸ | BTK | Q06187 | 5/20 | 0.41 |
| ▸ | FPR2 | P25090 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | ITK | Q08881 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.40 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | PIK3R5 | Q8WYR1 | 1/20 | 0.40 |
| ▸ | PIK3R3 | Q92569 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28829594 | 1.00 | JAK2 (0.45) | JAK2JAK1JAK3BTKFPR2 | |
| SCHEMBL29760783 | 1.00 | JAK2 (0.45) | JAK2JAK1JAK3BTKFPR2 | |
| SCHEMBL19353359 | 0.89 | BTK (0.42) | JAK2JAK1BTKFPR2EGFR | |
| SCHEMBL19332686 | 0.84 | JAK2 (0.50) | JAK2JAK1JAK3BTKEGFR | |
| SCHEMBL19332684 | 0.84 | JAK2 (0.50) | JAK2JAK1JAK3BTKEGFR | |
| SCHEMBL31693318 | 0.82 | JAK2 (0.54) | JAK2JAK1JAK3BTKFPR2 | |
| SCHEMBL19149801 | 0.82 | BTK (0.53) | BTK | |
| SCHEMBL31693347 | 0.82 | JAK2 (0.54) | JAK2JAK1JAK3BTKFPR2 | |
| SCHEMBL19149009 | 0.82 | BTK (0.53) | BTK | |
| SCHEMBL14630545 | 0.82 | JAK2 (0.68) | JAK2JAK1JAK3BTKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025202889-A1 | HER2 MUTATION INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2025-10-02 | — | — | WO | disclosed |
| CN-115746000-A | Compounds and methods for modulating bruton's tyrosine kinase | 嘉兴和剂药业有限公司 | 2023-03-07 | — | — | CN | disclosed |
| CN-109071455-B | Compounds and methods for modulating bruton's tyrosine kinase | 嘉兴和剂药业有限公司 | 2022-08-02 | — | — | CN | disclosed |
| US-11306099-B1 | Compounds and methods for modulating Bruton's Tyrosine Kinase | Angel Pharmaceutical Co., Ltd. (CN) | 2022-04-19 | — | — | US | disclosed |
| EP-3426637-B1 | COMPOUNDS AND METHODS FOR MODULATING BRUTON'S TYROSINE KINASE | ANGEL PHARMACEUTICAL CO LTD (CN) | 2022-02-09 | — | — | EP | disclosed |
| EP-3426637-B1 | COMPOUNDS AND METHODS FOR MODULATING BRUTON'S TYROSINE KINASE | ANGEL PHARMACEUTICAL CO LTD (CN) | 2022-02-09 | — | — | EP | disclosed |
| WO-2017156495-A1 | COMPOUNDS AND METHODS FOR MODULATING BRUTON'S TYROSINE KINASE | CORVUS PHARMACEUTICALS, INC. (US) | 2017-09-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11306099-B1 | Compounds and methods for modulating Bruton's Tyrosine Kinase | ABL1, BTK, LYN | JAK2 29/4885JAK1 112/4885JAK3 110/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.