Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 5/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | ITK | Q08881 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.40 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | PIK3R5 | Q8WYR1 | 1/20 | 0.40 |
| ▸ | PIK3R3 | Q92569 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 2/20 | 0.40 |
| ▸ | FPR2 | P25090 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28829594 | 0.89 | JAK2 (0.45) | BTKEGFRITKCYP3A4PIK3CD | |
| SCHEMBL29760783 | 0.89 | JAK2 (0.45) | BTKEGFRITKCYP3A4PIK3CD | |
| SCHEMBL19353358 | 0.89 | JAK2 (0.45) | BTKEGFRITKCYP3A4PIK3CD | |
| SCHEMBL19353357 | 0.81 | BTK (0.60) | BTKEGFRITKCYP3A4SRC | |
| SCHEMBL28829593 | 0.81 | BTK (0.60) | BTKEGFRITKCYP3A4SRC | |
| SCHEMBL29760800 | 0.81 | BTK (0.60) | BTKEGFRITKCYP3A4SRC | |
| SCHEMBL14654266 | 0.81 | BTK (0.55) | BTKEGFRITKPIK3CDPIK3CA | |
| SCHEMBL2731599 | 0.78 | EGFR (0.67) | BTKEGFRITKCYP3A4SRC | |
| SCHEMBL1128489 | 0.78 | EGFR (0.52) | BTKEGFRCYP3A4PIK3CDSRC | |
| SCHEMBL18599031 | 0.76 | BTK (0.55) | BTKEGFRITKPIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017156495-A1 | COMPOUNDS AND METHODS FOR MODULATING BRUTON'S TYROSINE KINASE | CORVUS PHARMACEUTICALS, INC. (US) | 2017-09-14 | — | — | WO | disclosed |