Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 10/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 8/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19355264 | 0.93 | TRPV1 (0.42) | CLK4CYP1A2CYP3A4ALDH1A1CYP2C19 | |
| SCHEMBL19355116 | 0.87 | CLK4 (0.38) | CLK4CYP1A2CYP3A4ALDH1A1CYP2C19 | |
| SCHEMBL19355263 | 0.83 | CLK4 (0.41) | CLK4CYP1A2CYP3A4ALDH1A1CYP2C19 | |
| SCHEMBL19355123 | 0.83 | CYP1A2 (0.38) | CLK4CYP1A2CYP3A4ALDH1A1CYP2C19 | |
| SCHEMBL22838684 | 0.82 | CYP1A2 (0.43) | CLK4CYP1A2CYP3A4ALDH1A1CYP2C19 | |
| SCHEMBL15343256 | 0.81 | PRKDC (0.39) | CLK4CYP1A2CYP3A4ALDH1A1CYP2C19 | |
| SCHEMBL19355393 | 0.80 | CLK4 (0.37) | CLK4CYP1A2CYP3A4ALDH1A1CYP2C19 | |
| SCHEMBL20842612 | 0.80 | NPC1 (0.35) | CLK4CYP1A2CYP3A4ALDH1A1CYP2C19 | |
| SCHEMBL19355394 | 0.79 | CLK4 (0.42) | CLK4CYP1A2CYP3A4ALDH1A1CYP2C19 | |
| SCHEMBL19355391 | 0.79 | CYP1A2 (0.42) | CLK4CYP1A2CYP3A4ALDH1A1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180193341-A1 | DNA-PK INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED | 2018-07-12 | — | — | US | disclosed |
| US-20170258789-A1 | DNA-PK INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2017-09-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170258789-A1 | DNA-PK INHIBITORS | POLK, DTYMK, DCK | CLK4 383/4885CYP1A2 2215/4885CYP3A4 1759/4885 |
| US-20180193341-A1 | DNA-PK INHIBITORS | POLK, DTYMK, DCK | CLK4 383/4885CYP1A2 2215/4885CYP3A4 1759/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.