Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 19/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22797342 | 0.97 | PDK2 (0.58) | PDK2CYP1A2 | |
| SCHEMBL19152841 | 0.89 | PDK2 (0.55) | PDK2 | |
| SCHEMBL22797340 | 0.89 | PDK2 (0.50) | PDK2 | |
| SCHEMBL21732768 | 0.88 | PDK2 (0.61) | PDK2CYP1A2 | |
| SCHEMBL22797613 | 0.87 | PDK2 (0.50) | PDK2CYP1A2 | |
| SCHEMBL19167894 | 0.85 | PDK2 (0.51) | PDK2CYP1A2 | |
| SCHEMBL22797542 | 0.85 | PDK2 (0.48) | PDK2CYP1A2 | |
| SCHEMBL19863928 | 0.85 | PDK2 (0.48) | PDK2CYP1A2 | |
| SCHEMBL22799489 | 0.84 | PDK2 (0.47) | PDK2CYP1A2 | |
| SCHEMBL22797538 | 0.84 | PDK2 (0.47) | PDK2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108779103-B | Compound with spirobifluorene structure | 默克专利有限公司 | 2021-12-28 | — | — | CN | disclosed |
| US-20190106391-A1 | COMPOUNDS WITH SPIROBIFLUORENE-STRUCTURES | MERCK PATENT GMBH (DE) | 2019-04-11 | — | — | US | disclosed |
| EP-3430006-A1 | COMPOUNDS WITH SPIROBIFLUORENE-STRUCTURES | Merck Patent GmbH (DE) | 2019-01-23 | — | — | EP | disclosed |
| WO-2017157983-A1 | COMPOUNDS WITH SPIROBIFLUORENE-STRUCTURES | MERCK PATENT GMBH (DE) | 2017-09-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190106391-A1 | COMPOUNDS WITH SPIROBIFLUORENE-STRUCTURES | TEC, NUDT1, DPYD | PDK2 157/4885CYP1A2 711/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.