SCHEMBL19360482

SCHEMBL19360482

CCS(=O)(=O)c1ccc(CNC(=O)c2ccc3c(c2)cc(Cc2ccc(C(F)(F)F)cc2F)n3C)cc1

nearest known ligand 0.65

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
RORC P51449 20/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19360339 0.91 RORC (0.64) RORC
SCHEMBL19360444 0.90 RORC (0.79) RORC
SCHEMBL19360320 0.90 RORC (0.82) RORC
SCHEMBL19360396 0.88 RORC (0.75) RORC
SCHEMBL19360567 0.88 RORC (0.60) RORC
SCHEMBL19360535 0.87 MAPT (0.51) RORC
SCHEMBL19360489 0.86 RORC (0.80) RORC
SCHEMBL19360478 0.82 RORC (0.69) RORC
SCHEMBL19360387 0.81 RORC (0.81) RORC
SCHEMBL28603444 0.81 RORC (0.63) RORC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107531679-B Aromatic amide derivative, preparation method and medical application thereof 江苏恒瑞医药股份有限公司 2021-07-02 CN disclosed
WO-2017157332-A1 AROMATIC AMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL APPLICATIONS THEREOF 江苏恒瑞医药股份有限公司 2017-09-21 WO disclosed