Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.38 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17244568 | 0.78 | CYP11B1 (0.48) | LMNATRPV1CYP11B1CYP11B2KLKB1 | |
| SCHEMBL3152671 | 0.77 | MEN1 (0.50) | LMNATRPV1RIPK1NPC1RAB9A | |
| SCHEMBL234833 | 0.74 | AOC3 (0.44) | LMNATRPV1CYP11B1CYP11B2KLKB1 | |
| SCHEMBL19224691 | 0.71 | CYP11B1 (0.39) | LMNATRPV1RIPK1CYP11B1CYP11B2 | |
| SCHEMBL9863340 | 0.71 | LMNA (0.40) | LMNATRPV1CYP11B1CYP11B2KLKB1 | |
| SCHEMBL27876055 | 0.71 | KLKB1 (0.40) | LMNARIPK1CYP11B1CYP11B2KLKB1 | |
| SCHEMBL554466 | 0.70 | KLKB1 (0.49) | RIPK1KLKB1 | |
| SCHEMBL235295 | 0.70 | LMNA (0.44) | LMNATRPV1NPC1RAB9AHPGD | |
| SCHEMBL2754067 | 0.70 | KDM4E (0.53) | LMNARIPK1NPC1RAB9AHPGD | |
| SCHEMBL29256156 | 0.68 | KLKB1 (0.47) | LMNARIPK1CYP11B1CYP11B2KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3219709-A1 | INTERMEDIATE COMPOUND OF MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | Vertex Pharmaceuticals Incorporated (US) | 2017-09-20 | — | — | EP | disclosed |