Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 6/20 | 0.82 |
| ▸ | EGFR | P00533 | 16/20 | 0.77 |
| ▸ | ITK | Q08881 | 5/20 | 0.77 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.61 |
| ▸ | JAK3 | P52333 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9925020 | 0.92 | BTK (0.79) | BTKEGFRITKJAK3 | |
| SCHEMBL12519715 | 0.91 | BTK (0.77) | BTKEGFRITK | |
| SCHEMBL2230183 | 0.90 | BTK (1.00) | BTKEGFRITKJAK3 | |
| SCHEMBL2352426 | 0.90 | BTK (1.00) | BTKEGFRITKJAK3 | |
| SCHEMBL9923759 | 0.89 | EGFR (0.81) | BTKEGFRITK | |
| SCHEMBL13606336 | 0.87 | EGFR (1.00) | BTKEGFRITKJAK3 | |
| SCHEMBL2350876 | 0.87 | EGFR (1.00) | BTKEGFRITKJAK3 | |
| SCHEMBL2348879 | 0.87 | EGFR (0.83) | BTKEGFRITKMAPK3JAK3 | |
| SCHEMBL12518710 | 0.86 | BTK (0.84) | BTKEGFRITKJAK3 | |
| SCHEMBL28080977 | 0.86 | BTK (0.88) | BTKEGFRITKJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765038-B2 | Heteroaryl compounds and uses thereof | CELGENE CAR LLC (BM) | 2017-09-19 | — | — | US | disclosed |