Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 7/20 | 0.88 |
| ▸ | EGFR | P00533 | 16/20 | 0.86 |
| ▸ | ITK | Q08881 | 6/20 | 0.86 |
| ▸ | JAK3 | P52333 | 2/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2352426 | 0.93 | BTK (1.00) | BTKEGFRITKJAK3 | |
| SCHEMBL2230183 | 0.93 | BTK (1.00) | BTKEGFRITKJAK3 | |
| SCHEMBL13606336 | 0.92 | EGFR (1.00) | BTKEGFRITKJAK3 | |
| SCHEMBL2350876 | 0.92 | EGFR (1.00) | BTKEGFRITKJAK3 | |
| SCHEMBL13165494 | 0.92 | BTK (0.84) | BTKEGFRITKJAK3 | |
| SCHEMBL18165623 | 0.90 | EGFR (0.82) | BTKEGFRITKJAK3 | |
| SCHEMBL27831797 | 0.89 | EGFR (0.84) | BTKEGFRITKJAK3 | |
| SCHEMBL12518710 | 0.89 | BTK (0.84) | BTKEGFRITKJAK3 | |
| SCHEMBL12518706 | 0.88 | EGFR (1.00) | BTKEGFRITKJAK3 | |
| SCHEMBL13606253 | 0.88 | BTK (0.82) | BTKEGFRITKJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108047142-A | Heteroaryl compound and its purposes | 阿维拉制药公司 | 2018-05-18 | — | — | CN | disclosed |
| CN-106146407-A | Heteroaryl compound and its purposes | 阿维拉制药公司 | 2016-11-23 | — | — | CN | disclosed |
| CN-102740847-B | Heteroaryl compounds and uses thereof | 阿维拉制药公司 | 2016-06-29 | — | — | CN | disclosed |
| CN-102740847-A | Heteroaryl compounds and uses thereof | AVILA THERAPEUTICS INC | 2012-10-17 | — | — | CN | disclosed |
| CN-102083800-A | Heteroaryl compounds and uses thereof | AVILA THERAPEUTICS AND USES TH | 2011-06-01 | — | — | CN | disclosed |