Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.87 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.71 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.71 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.71 |
| ▸ | BTK | Q06187 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2718173 | 0.93 | EGFR (1.00) | EGFRERBB2ERBB3ERBB4BTK | |
| SCHEMBL19360704 | 0.91 | EGFR (0.72) | EGFRBTK | |
| SCHEMBL9923764 | 0.90 | EGFR (1.00) | EGFRERBB2ERBB3ERBB4BTK | |
| SCHEMBL19360699 | 0.90 | EGFR (0.87) | EGFR | |
| SCHEMBL19360701 | 0.87 | EGFR (0.88) | EGFRERBB4BTK | |
| SCHEMBL5584198 | 0.87 | EGFR (1.00) | EGFRERBB2ERBB3ERBB4BTK | |
| SCHEMBL5584209 | 0.86 | EGFR (1.00) | EGFRERBB2ERBB3ERBB4BTK | |
| SCHEMBL9923762 | 0.85 | EGFR (0.82) | EGFRBTK | |
| SCHEMBL16407979 | 0.83 | EGFR (1.00) | EGFRERBB2ERBB3ERBB4BTK | |
| SCHEMBL2716652 | 0.82 | EGFR (1.00) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765038-B2 | Heteroaryl compounds and uses thereof | CELGENE CAR LLC (BM) | 2017-09-19 | — | — | US | disclosed |