Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 7/20 | 0.57 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.57 |
| ▸ | CDK1 | P06493 | 2/20 | 0.57 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.57 |
| ▸ | GSK3A | P49840 | 2/20 | 0.57 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.57 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.57 |
| ▸ | CDK2 | P24941 | 1/20 | 0.57 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.57 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.57 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.57 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.57 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.57 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.39 |
| ▸ | IDH1 | O75874 | 3/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | VNN1 | O95497 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12552315 | 0.91 | GSK3B (0.67) | GSK3BCCNB2CDK1CCNB1GSK3A | |
| Laduviglusib SCHEMBL29381114 | 0.86 | GSK3B (0.77) | GSK3BCCNB2CDK1CCNB1GSK3A | |
| Laduviglusib SCHEMBL29838591 | 0.86 | GSK3B (0.77) | GSK3BCCNB2CDK1CCNB1GSK3A | |
| Laduviglusib SCHEMBL240280 | 0.86 | GSK3B (0.77) | GSK3BCCNB2CDK1CCNB1GSK3A | |
| Laduviglusib SCHEMBL17165152 | 0.85 | GSK3B (0.76) | GSK3BCCNB2CDK1CCNB1GSK3A | |
| SCHEMBL5094723 | 0.85 | GSK3B (0.66) | GSK3BCCNB2CDK1CCNB1GSK3A | |
| SCHEMBL4398952 | 0.85 | GSK3B (0.65) | GSK3BCCNB2CDK1CCNB1GSK3A | |
| SCHEMBL5094545 | 0.80 | GSK3B (0.68) | GSK3BCCNB2CDK1CCNB1GSK3A | |
| SCHEMBL4404427 | 0.77 | GSK3B (0.64) | GSK3BCCNB2CDK1CCNB1GSK3A | |
| SCHEMBL20095066 | 0.76 | GSK3B (0.72) | GSK3BCCNB2CDK1CCNB1GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11401510-B2 | Generation of airway basal stem cells from human pluripotent stem cells | TRUSTEES OF BOSTON UNIVERSITY (US) | 2022-08-02 | — | — | US | disclosed |
| EP-3303564-B1 | METHODS OF IN VITRO DIFFERENTIATION OF MIDBRAIN DOPAMINE (MDA) NEURONS | MEMORIAL SLOAN KETTERING CANCER CENTER (US) | 2022-02-23 | — | — | EP | disclosed |
| EP-3429603-B1 | METHODS AND COMPOSITIONS RELATING TO HEMATOPOIETIC STEM CELL EXPANSION | CHILDRENS MEDICAL CENTER (US) | 2021-12-29 | — | — | EP | disclosed |
| US-20210254016-A1 | GENERATION OF AIRWAY BASAL STEM CELLS FROM HUMAN PLURIPOTENT STEM CELLS | TRUSTEES OF BOSTON UNIVERSITY (US) | 2021-08-19 | — | — | US | disclosed |
| US-20200248143-A1 | METHODS AND COMPOSITIONS RELATING TO HEMATOPOIETIC STEM CELL EXPANSION, ENRICHMENT, AND MAINTENANCE | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2020-08-06 | — | — | US | disclosed |
| US-10669528-B2 | Methods and compositions relating to hematopoietic stem cell expansion, enrichment, and maintenance | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2020-06-02 | — | — | US | disclosed |
| US-20190119642-A1 | METHODS AND COMPOSITIONS RELATING TO HEMATOPOIETIC STEM CELL EXPANSION | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2019-04-25 | — | — | US | disclosed |
| US-20180187156-A1 | METHODS AND COMPOSITIONS RELATING TO HEMATOPOIETIC STEM CELL EXPANSION, ENRICHMENT, AND MAINTENANCE | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2018-07-05 | — | — | US | disclosed |
| WO-2017161001-A1 | METHODS AND COMPOSITIONS RELATING TO HEMATOPOIETIC STEM CELL EXPANSION | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2017-09-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200248143-A1 | METHODS AND COMPOSITIONS RELATING TO HEMATOPOIETIC STEM CELL EXPANSION, ENRICHMENT, AND MAINTENANCE | HDAC1, EHMT1, MCL1 | GSK3B 35/4885CCNB2 1873/4885CDK1 726/4885 |
| US-20180187156-A1 | METHODS AND COMPOSITIONS RELATING TO HEMATOPOIETIC STEM CELL EXPANSION, ENRICHMENT, AND MAINTENANCE | HDAC1, EHMT1, MCL1 | GSK3B 35/4885CCNB2 1873/4885CDK1 726/4885 |
| US-20210254016-A1 | GENERATION OF AIRWAY BASAL STEM CELLS FROM HUMAN PLURIPOTENT STEM CELLS | KRT18, CFTR, MCOLN3 | GSK3B 3246/4885CCNB2 4618/4885CDK1 4793/4885 |
| US-10669528-B2 | Methods and compositions relating to hematopoietic stem cell expansion, enrichment, and maintenance | HDAC1, EHMT1, MCL1 | GSK3B 35/4885CCNB2 1873/4885CDK1 726/4885 |
| US-11401510-B2 | Generation of airway basal stem cells from human pluripotent stem cells | KRT18, CFTR, MCOLN3 | GSK3B 3246/4885CCNB2 4618/4885CDK1 4793/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.