Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | BDKRB1 | P46663 | 11/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3237884 | 0.89 | USP2 (0.41) | KMT2AMEN1USP2MAPTBDKRB1 | |
| SCHEMBL1935333 | 0.84 | MAPK1 (0.44) | KMT2AMAPTBDKRB1ALDH1A1CYP3A4 | |
| SCHEMBL938115 | 0.82 | MEN1 (0.51) | KMT2AMEN1USP2MAPTBDKRB1 | |
| SCHEMBL2236993 | 0.82 | USP2 (0.43) | KMT2AMEN1USP2MAPTBDKRB1 | |
| SCHEMBL1936190 | 0.80 | MEN1 (0.45) | KMT2AMEN1USP2MAPTBDKRB1 | |
| SCHEMBL937908 | 0.79 | MEN1 (0.48) | KMT2AMEN1USP2MAPTBDKRB1 | |
| SCHEMBL16611857 | 0.78 | HPGD (0.44) | KMT2AMEN1ALDH1A1CYP3A4HPGD | |
| SCHEMBL1936197 | 0.78 | MEN1 (0.46) | KMT2AMEN1USP2MAPTBDKRB1 | |
| SCHEMBL1936194 | 0.77 | MEN1 (0.42) | KMT2AMEN1USP2MAPTBDKRB1 | |
| SCHEMBL2236591 | 0.75 | MEN1 (0.41) | KMT2AMEN1USP2MAPTBDKRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140073627-A1 | BRADYKININ B1 ANTAGONISTS | EVOTEC AG (DE) | 2014-03-13 | — | — | US | disclosed |
| US-8623859-B2 | Bradykinin B1 antagonists | EVOTEC AG (DE) | 2014-01-07 | — | — | US | disclosed |
| US-8623859-B2 | Bradykinin B1 antagonists | EVOTEC AG (DE) | 2014-01-07 | — | — | US | disclosed |
| US-20110201589-A1 | NEW BRADYKININ B1 ANTAGONISTS | EVOTEC AG (DE) | 2011-08-18 | — | — | US | disclosed |
| US-20110201589-A1 | NEW BRADYKININ B1 ANTAGONISTS | EVOTEC AG (DE) | 2011-08-18 | — | — | US | disclosed |
| EP-2331518-A1 | NEW BRADYKININ B1 ANTAGONISTS | Evotec AG (DE) | 2011-06-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140073627-A1 | BRADYKININ B1 ANTAGONISTS | BDKRB1, BDKRB2, BRS3 | KMT2A 1859/4885MEN1 231/4885USP2 4171/4885 |
| US-20110201589-A1 | NEW BRADYKININ B1 ANTAGONISTS | BDKRB1, BDKRB2, BRS3 | KMT2A 2057/4885MEN1 349/4885USP2 3985/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.