Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19362221 | 0.96 | KDM4E (0.33) | KDM4EALDH1A1CYP1A2HPGD | |
| SCHEMBL19362373 | 0.80 | PDE10A (0.34) | KDM4EALDH1A1CYP1A2HPGD | |
| SCHEMBL19362368 | 0.80 | — | — | |
| SCHEMBL19362417 | 0.80 | PDE10A (0.34) | KDM4EALDH1A1CYP1A2HPGD | |
| SCHEMBL17517570 | 0.69 | KDM4E (0.33) | KDM4EALDH1A1CYP1A2HPGD | |
| SCHEMBL13153128 | 0.69 | KDM4E (0.63) | KDM4EALDH1A1HPGD | |
| SCHEMBL5440063 | 0.69 | KDM4E (0.57) | KDM4EALDH1A1CYP1A2HPGD | |
| SCHEMBL19362352 | 0.68 | HIF1A (0.36) | — | |
| SCHEMBL19362227 | 0.68 | HIF1A (0.36) | KDM4EALDH1A1 | |
| SCHEMBL18568567 | 0.67 | KDM4E (0.61) | KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170267679-A1 | TRICYCLIC FUSED PYRIMIDINE COMPOUNDS AS INHIBITORS OF p97 COMPLEX | CLEAVE BIOSCIENCES INC (US) | 2017-09-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170267679-A1 | TRICYCLIC FUSED PYRIMIDINE COMPOUNDS AS INHIBITORS OF p97 COMPLEX | PSMG3, PSME1, PSMB3 | KDM4E 3241/4885ALDH1A1 3234/4885CYP1A2 3254/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.