Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 16/20 | 0.48 |
| ▸ | HRH4 | Q9H3N8 | 9/20 | 0.48 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.45 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.45 |
| ▸ | ITGAL | P20701 | 1/20 | 0.45 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19364630 | 0.90 | HRH3 (0.50) | HRH3HRH4ITGB2ICAM1ITGAL | |
| SCHEMBL888751 | 0.88 | ITGB2 (0.47) | HRH3HRH4ITGB2ICAM1ITGAL | |
| SCHEMBL10122812 | 0.88 | ITGB2 (0.47) | HRH3HRH4ITGB2ICAM1ITGAL | |
| SCHEMBL12979930 | 0.83 | ITGB2 (0.47) | HRH3HRH4ITGB2ICAM1ITGAL | |
| SCHEMBL13187470 | 0.83 | ITGB2 (0.49) | HRH3HRH4ITGB2ICAM1ITGAL | |
| SCHEMBL6806998 | 0.83 | ITGB2 (0.62) | ITGB2ICAM1ITGALSLC6A5ALDH1A1 | |
| SCHEMBL8906903 | 0.80 | HRH3 (0.47) | HRH3HRH4ITGB2ICAM1ITGAL | |
| SCHEMBL17570989 | 0.76 | ITGB2 (0.39) | HRH3HRH4ITGB2ICAM1ITGAL | |
| SCHEMBL14961160 | 0.75 | ITGB2 (0.49) | HRH3HRH4ITGB2ICAM1ITGAL | |
| SCHEMBL14961161 | 0.75 | ITGB2 (0.49) | HRH3HRH4ITGB2ICAM1ITGAL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765087-B2 | Benzimidazole derivatives | ENANTA PHARMACEUTICALS, INC. (US) | 2017-09-19 | — | — | US | disclosed |