Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 6/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.43 |
| ▸ | ATR | Q13535 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365310 | 0.90 | TSHR (0.45) | CNR2MCHR1ATRGRM5 | |
| SCHEMBL19365636 | 0.88 | POLB (0.46) | MCHR1MEN1KMT2A | |
| SCHEMBL19703381 | 0.87 | GRM5 (0.42) | CNR2MCHR1ATRMEN1KMT2A | |
| SCHEMBL19365710 | 0.86 | CNR2 (0.52) | CNR2MCHR1ATRCNR1GRM5 | |
| SCHEMBL19365466 | 0.86 | CNR2 (0.40) | CNR2MCHR1ATRGRM5ROCK2 | |
| SCHEMBL19706060 | 0.83 | BRAF (0.42) | CNR2MCHR1ATRKMT2ACNR1 | |
| SCHEMBL19706193 | 0.82 | CNR2 (0.40) | CNR2MCHR1ATRMEN1KMT2A | |
| SCHEMBL19365604 | 0.80 | HDAC1 (0.46) | ATRMEN1KMT2AATMCYP3A4 | |
| SCHEMBL19365311 | 0.80 | CNR2 (0.39) | CNR2MCHR1ATRCNR1GRM5 | |
| SCHEMBL19365616 | 0.79 | P2RY1 (0.40) | CNR2MCHR1KMT2ACNR1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |