Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | GRM5 | P41594 | 3/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.34 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365308 | 0.90 | FGFR4 (0.35) | TP53FAAHFGFR4CYP2C9ALOX5AP | |
| SCHEMBL19365705 | 0.90 | MAP4K4 (0.38) | FAAHFGFR4CYP2C9ALOX5APKCNH2 | |
| SCHEMBL19670449 | 0.89 | KDR (0.40) | FAAHMCHR1 | |
| SCHEMBL19365374 | 0.88 | MCHR1 (0.41) | FAAHFGFR4CYP2C9ALOX5APKCNH2 | |
| SCHEMBL19365601 | 0.88 | CNR1 (0.36) | CNR2GRM5CNR1FAAHFGFR4 | |
| SCHEMBL19365616 | 0.88 | P2RY1 (0.40) | CNR2TP53GRM5CNR1MCHR1 | |
| SCHEMBL19365450 | 0.88 | HDAC1 (0.41) | FAAHFGFR4CYP2C9ALOX5APKCNH2 | |
| SCHEMBL19365497 | 0.85 | ALOX5AP (0.40) | TP53FAAHFGFR4CYP2C9ALOX5AP | |
| SCHEMBL19670248 | 0.85 | ATR (0.41) | FAAHFGFR4KCNH2SYKATR | |
| SCHEMBL19670256 | 0.85 | FGFR4 (0.36) | TP53FAAHFGFR4CYP2C9ALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |