Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH2 | P48735 | 13/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16785606 | 0.84 | IDH2 (0.40) | IDH2LRRK2MEN1ALDH1A1KMT2A | |
| SCHEMBL19706975 | 0.82 | IDH2 (0.36) | IDH2LRRK2MAPK14KDM1AMAOA | |
| SCHEMBL19706095 | 0.82 | CHRM3 (0.41) | IDH2APP | |
| SCHEMBL19706685 | 0.81 | IDH2 (0.41) | IDH2KDM1AMAOAMAOBMEN1 | |
| SCHEMBL19365411 | 0.79 | IDH2 (0.40) | IDH2MEN1ALDH1A1KMT2A | |
| SCHEMBL19706172 | 0.79 | IDH2 (0.40) | IDH2KDM1AMAOAMAOBPIM1 | |
| SCHEMBL19365673 | 0.79 | RHOA (0.39) | IDH2MAPK14KDM1AMAOAMAOB | |
| SCHEMBL19706045 | 0.79 | IDH2 (0.35) | IDH2KDM1AMAOAMAOB | |
| SCHEMBL19365803 | 0.78 | MAPK13 (0.46) | IDH2MAPK14 | |
| SCHEMBL19706914 | 0.78 | IDH2 (0.38) | IDH2KDM1AMAOAMAOBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |