Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHOA | P61586 | 1/20 | 0.39 |
| ▸ | IDH2 | P48735 | 10/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 2/20 | 0.32 |
| ▸ | MAOA | P21397 | 2/20 | 0.32 |
| ▸ | MAOB | P27338 | 2/20 | 0.32 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.32 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.32 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365242 | 0.91 | MAPK14 (0.37) | RHOAIDH2CNR2MAPK13MAPK12 | |
| SCHEMBL19670542 | 0.86 | RHOA (0.39) | RHOAIDH2MAPK13MAPK12MAPK11 | |
| SCHEMBL16238714 | 0.84 | RHOA (0.43) | RHOAIDH2KDM1AMAOAMAOB | |
| SCHEMBL19706172 | 0.82 | IDH2 (0.40) | IDH2KDM1AMAOAMAOBRPS6KB1 | |
| SCHEMBL19365701 | 0.81 | RHOA (0.35) | RHOAIDH2 | |
| SCHEMBL19706045 | 0.81 | IDH2 (0.35) | IDH2CNR2KDM1AMAOAMAOB | |
| SCHEMBL19865069 | 0.81 | RHOA (0.48) | RHOAIDH2 | |
| SCHEMBL16249983 | 0.81 | RHOA (0.48) | RHOAIDH2 | |
| SCHEMBL16250011 | 0.81 | RHOA (0.48) | RHOAIDH2 | |
| SCHEMBL16238182 | 0.81 | RHOA (0.45) | RHOAIDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |