Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.35 |
| ▸ | ITK | Q08881 | 1/20 | 0.35 |
| ▸ | SCD | O00767 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 3/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.34 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.33 |
| ▸ | HSD17B14 | Q9BPX1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17618620 | 1.00 | CNR1 (0.36) | CNR1SMN1; SMN2DEGS1ITKSCD | |
| SCHEMBL17618533 | 1.00 | CNR1 (0.36) | CNR1SMN1; SMN2DEGS1ITKSCD | |
| SCHEMBL20633001 | 0.91 | ITK (0.34) | CNR1SMN1; SMN2DEGS1ITKSCD | |
| SCHEMBL20631815 | 0.91 | ITK (0.34) | CNR1SMN1; SMN2DEGS1ITKSCD | |
| SCHEMBL20632386 | 0.91 | ITK (0.34) | CNR1SMN1; SMN2DEGS1ITKSCD | |
| SCHEMBL17618617 | 0.89 | ABL1 (0.38) | CNR1SMN1; SMN2GRM5ABL1 | |
| SCHEMBL19365532 | 0.89 | ABL1 (0.38) | CNR1SMN1; SMN2GRM5ABL1 | |
| SCHEMBL17618538 | 0.89 | ABL1 (0.38) | CNR1SMN1; SMN2GRM5ABL1 | |
| SCHEMBL17618446 | 0.88 | GRM5 (0.42) | CNR1DEGS1ITKGRM5HCRTR1 | |
| SCHEMBL17618629 | 0.88 | CNR1 (0.36) | CNR1SMN1; SMN2GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |