Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | BCR | P11274 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 3/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | VCP | P55072 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.34 |
| ▸ | TP53BP1 | Q12888 | 2/20 | 0.34 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17618538 | 1.00 | ABL1 (0.38) | ABL1BCRBTKCNR1SMN1; SMN2 | |
| SCHEMBL17618617 | 1.00 | ABL1 (0.38) | ABL1BCRBTKCNR1SMN1; SMN2 | |
| SCHEMBL17618545 | 0.91 | CNR1 (0.36) | CNR1SMN1; SMN2GSK3BDYRK1AGRM5 | |
| SCHEMBL17618629 | 0.91 | CNR1 (0.36) | CNR1SMN1; SMN2GSK3BDYRK1AGRM5 | |
| SCHEMBL20633225 | 0.91 | BTK (0.34) | ABL1BCRBTKCNR1SMN1; SMN2 | |
| SCHEMBL19699057 | 0.90 | BTK (0.39) | BTKCNR2GSK3BDYRK1AGRM5 | |
| SCHEMBL19365286 | 0.89 | CNR1 (0.36) | ABL1CNR1SMN1; SMN2GRM5 | |
| SCHEMBL17618533 | 0.89 | CNR1 (0.36) | ABL1CNR1SMN1; SMN2GRM5 | |
| SCHEMBL17618620 | 0.89 | CNR1 (0.36) | ABL1CNR1SMN1; SMN2GRM5 | |
| SCHEMBL17618614 | 0.88 | CNR2 (0.49) | BTKCNR1CNR2GRM5KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |