Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 10/20 | 0.41 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17618586 | 1.00 | USP30 (0.45) | USP30LRRK2MAP4K1HSD11B1PDE4D | |
| SCHEMBL17618514 | 1.00 | USP30 (0.45) | USP30LRRK2MAP4K1HSD11B1PDE4D | |
| SCHEMBL17618444 | 0.95 | USP30 (0.42) | USP30LRRK2HSD11B1PDE4DPDE4A | |
| SCHEMBL19704835 | 0.94 | USP30 (0.43) | USP30LRRK2MAP4K1HSD11B1PDE4D | |
| SCHEMBL17618600 | 0.91 | USP30 (0.44) | USP30LRRK2MAP4K1HSD11B1PDE4D | |
| SCHEMBL17618587 | 0.91 | USP30 (0.42) | USP30LRRK2MAP4K1HSD11B1PRKCQ | |
| SCHEMBL17618752 | 0.91 | GSK3B (0.39) | USP30HSD11B1 | |
| SCHEMBL20632191 | 0.91 | USP30 (0.41) | USP30LRRK2MAP4K1PDE4DPRKCQ | |
| SCHEMBL17618512 | 0.90 | USP30 (0.41) | USP30LRRK2MAP4K1HSD11B1PDE4D | |
| SCHEMBL19365746 | 0.90 | USP30 (0.41) | USP30LRRK2MAP4K1HSD11B1PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |