Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 13/20 | 0.40 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17618514 | 0.91 | USP30 (0.45) | USP30LRRK2MAP4K1PDE4DPRKCQ | |
| SCHEMBL17618586 | 0.91 | USP30 (0.45) | USP30LRRK2MAP4K1PDE4DPRKCQ | |
| SCHEMBL19365376 | 0.91 | USP30 (0.45) | USP30LRRK2MAP4K1PDE4DPRKCQ | |
| SCHEMBL20633151 | 0.89 | LRRK2 (0.39) | USP30LRRK2MAP4K1PRKCQJAK2 | |
| SCHEMBL20633225 | 0.86 | BTK (0.34) | MAP4K1 | |
| SCHEMBL17618444 | 0.85 | USP30 (0.42) | USP30LRRK2PDE4D | |
| SCHEMBL20631740 | 0.85 | LRRK2 (0.38) | LRRK2MAP4K1PDE4DPRKCQJAK2 | |
| SCHEMBL20632798 | 0.85 | LRRK2 (0.42) | LRRK2MAP4K1PRKCQJAK2JAK1 | |
| SCHEMBL19704835 | 0.84 | USP30 (0.43) | USP30LRRK2MAP4K1PDE4D | |
| SCHEMBL17618587 | 0.81 | USP30 (0.42) | USP30LRRK2MAP4K1PRKCQJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997029-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2019-01-09 | — | — | EP | disclosed |