Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 8/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.36 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.36 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.36 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17618516 | 1.00 | LRRK2 (0.40) | LRRK2MCHR1HDAC2CNR1MAP4K1 | |
| SCHEMBL17618585 | 1.00 | LRRK2 (0.40) | LRRK2MCHR1HDAC2CNR1MAP4K1 | |
| SCHEMBL17618482 | 0.95 | HDAC2 (0.39) | LRRK2MCHR1HDAC2CNR1HSD11B1 | |
| SCHEMBL19706070 | 0.94 | LRRK2 (0.38) | LRRK2MCHR1HDAC2CNR1MAP4K1 | |
| SCHEMBL17618740 | 0.92 | ABL1 (0.38) | HSD11B1DGAT2 | |
| SCHEMBL17770603 | 0.89 | CACNA1G (0.40) | LRRK2CNR1MAP4K1HSD11B1USP30 | |
| SCHEMBL17618505 | 0.89 | CACNA1G (0.40) | LRRK2CNR1MAP4K1HSD11B1USP30 | |
| SCHEMBL16238326 | 0.89 | CACNA1G (0.40) | LRRK2CNR1MAP4K1HSD11B1USP30 | |
| SCHEMBL17618674 | 0.87 | PIM2 (0.43) | — | |
| SCHEMBL17618515 | 0.87 | HDAC2 (0.42) | LRRK2MCHR1HDAC2MAP4K1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |