Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 8/20 | 0.34 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365551 | 0.91 | PIM2 (0.34) | PIM2PIM3GSK3BFAAHPIM1 | |
| SCHEMBL19706239 | 0.90 | BTK (0.34) | PIM2PIM3GRM5FGFR4BTK | |
| SCHEMBL17618714 | 0.89 | PRMT5 (0.40) | PIM2PIM3GRM5FGFR4BTK | |
| SCHEMBL17618686 | 0.89 | GSK3B (0.37) | PIM2PIM3TRPV1GRM5BTK | |
| SCHEMBL17618633 | 0.89 | GRM5 (0.39) | PIM2PIM3GRM5BTKDGAT2 | |
| SCHEMBL16238017 | 0.88 | TRPV1 (0.39) | PIM2PIM3TRPV1DYRK1APIM1 | |
| SCHEMBL16238662 | 0.88 | TRPV1 (0.39) | PIM2PIM3TRPV1DYRK1APIM1 | |
| SCHEMBL17618661 | 0.88 | PIM3 (0.44) | PIM2PIM3GRM5BTKFAAH | |
| SCHEMBL19365639 | 0.87 | PIM2 (0.38) | PIM2PIM3GRM5BTKDGAT2 | |
| SCHEMBL17618752 | 0.87 | GSK3B (0.39) | PIM2PIM3BTKDGAT2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |