Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM2 | Q9P1W9 | 7/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 5/20 | 0.38 |
| ▸ | WNT1 | P04628 | 2/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 5/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 3/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365550 | 0.91 | PIM2 (0.37) | PIM2PIM3FAAHPIM1ATR | |
| SCHEMBL17618633 | 0.88 | GRM5 (0.39) | PIM2PIM3DYRK1AGRM5BTK | |
| SCHEMBL17618686 | 0.88 | GSK3B (0.37) | PIM2PIM3DYRK1AGRM5BTK | |
| SCHEMBL17618714 | 0.88 | PRMT5 (0.40) | PIM2PIM3DYRK1AGRM5BTK | |
| SCHEMBL17618661 | 0.87 | PIM3 (0.44) | PIM2PIM3GRM5BTKFAAH | |
| SCHEMBL19365637 | 0.87 | PIM2 (0.35) | PIM2PIM3DYRK1AGRM5BTK | |
| SCHEMBL16238662 | 0.86 | TRPV1 (0.39) | PIM2PIM3DYRK1APIM1 | |
| SCHEMBL16238017 | 0.86 | TRPV1 (0.39) | PIM2PIM3DYRK1APIM1 | |
| SCHEMBL17618752 | 0.86 | GSK3B (0.39) | PIM2PIM3DYRK1ABTKDGAT2 | |
| SCHEMBL17618606 | 0.85 | PIK3C3 (0.40) | PIM2PIM3DYRK1ABTKDGAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |