Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19364790 | 0.96 | TLR8 (0.42) | MAPK1KDM4EALDH1A1HPGDTLR8 | |
| SCHEMBL19365825 | 0.84 | MCHR1 (0.40) | TLR8CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL19365367 | 0.82 | TLR8 (0.40) | HPGDTLR8ITGB3ITGA2B | |
| SCHEMBL19365661 | 0.82 | MEN1 (0.39) | TLR8NAMPTITGB3ITGA2B | |
| SCHEMBL19706158 | 0.81 | NAMPT (0.42) | MAPK1KDM4EALDH1A1HPGDLMNA | |
| SCHEMBL19670322 | 0.79 | MAPK1 (0.38) | MAPK1KDM4EALDH1A1HPGDLMNA | |
| SCHEMBL19706248 | 0.79 | NAMPT (0.40) | MAPK1KDM4EALDH1A1HPGDLMNA | |
| SCHEMBL19365846 | 0.78 | TLR8 (0.41) | TLR8 | |
| SCHEMBL19670314 | 0.76 | CA1 (0.49) | MAPK1TLR8LMNAMAPTHTT | |
| SCHEMBL19365544 | 0.76 | TLR8 (0.41) | MAPK1ALDH1A1HPGDTLR8LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |