Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | KIFC1 | Q9BW19 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 4/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 2/20 | 0.36 |
| ▸ | CTSK | P43235 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365661 | 0.92 | MEN1 (0.39) | MCHR1EPHB4TLR8CA12CA1 | |
| SCHEMBL19365367 | 0.89 | TLR8 (0.40) | MCHR1TLR8CA12CA1CA2 | |
| SCHEMBL19364790 | 0.85 | TLR8 (0.42) | EPHB4TLR8ITGB3ITGA2BCYP1A2 | |
| SCHEMBL19365656 | 0.84 | MAPK1 (0.42) | TLR8ITGB3ITGA2BCYP1A2CYP3A4 | |
| SCHEMBL19670398 | 0.79 | CTSK (0.38) | EPHB4CA12CA1CA2CA9 | |
| SCHEMBL19365544 | 0.79 | TLR8 (0.41) | EPHB4TLR8 | |
| SCHEMBL19365846 | 0.79 | TLR8 (0.41) | MCHR1TLR8PIK3CDPIK3CAPIK3CG | |
| SCHEMBL19364780 | 0.79 | EPHB4 (0.41) | EPHB4TLR8PIK3CDPIK3CAPIK3CG | |
| SCHEMBL19365630 | 0.78 | CTSK (0.38) | EPHB4CA12CA1CA2CA9 | |
| SCHEMBL19670314 | 0.78 | CA1 (0.49) | TLR8CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |