Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 4/20 | 0.64 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | EDNRA | P25101 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.34 |
| ▸ | ACLY | P53396 | 1/20 | 0.34 |
| ▸ | NMT1 | P30419 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9281044 | 0.80 | HDAC4 (0.54) | HDAC4BRD4KMT2APDK1EDNRA | |
| SCHEMBL786747 | 0.80 | HDAC4 (0.52) | HDAC4BRD4KMT2APDK1EDNRA | |
| SCHEMBL12498360 | 0.79 | HDAC4 (1.00) | HDAC4 | |
| SCHEMBL12498469 | 0.79 | HDAC4 (0.82) | HDAC4 | |
| SCHEMBL15783740 | 0.79 | HDAC4 (0.74) | HDAC4 | |
| SCHEMBL12498354 | 0.79 | HDAC4 (1.00) | HDAC4 | |
| Hydrochloric Acid SCHEMBL28830016 | 0.78 | HDAC4 (0.51) | HDAC4BRD4KMT2APDK1EDNRA | |
| SCHEMBL5921550 | 0.78 | HDAC4 (0.51) | HDAC4BRD4KMT2APDK1EDNRA | |
| SCHEMBL15768592 | 0.73 | HDAC4 (0.58) | HDAC4BRD4PDK1EDNRAESR1 | |
| SCHEMBL77337 | 0.73 | HDAC4 (0.47) | HDAC4BRD4KMT2AEDNRAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765054-B2 | Histone deacetylase inhibitors and compositions and methods of use thereof | CHDI FOUNDATION, INC. (US) | 2017-09-19 | — | — | US | disclosed |