Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 2/20 | 0.64 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | OXTR | P30559 | 3/20 | 0.38 |
| ▸ | AVPR1A | P37288 | 3/20 | 0.38 |
| ▸ | AVPR2 | P30518 | 2/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KAT6A | Q92794 | 3/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12498435 | 0.82 | HDAC4 (0.77) | HDAC4HTTRAB9AMAPTNPC1 | |
| SCHEMBL12499085 | 0.78 | HDAC4 (1.00) | HDAC4 | |
| SCHEMBL15783746 | 0.76 | HDAC4 (0.67) | HDAC4HTTRAB9ANPC1GAA | |
| SCHEMBL5097563 | 0.76 | HTT (0.53) | HDAC4HTTRAB9AMAPTNPC1 | |
| SCHEMBL19366420 | 0.76 | HDAC4 (0.60) | HDAC4MAPTNPC1KDM4EALDH1A1 | |
| SCHEMBL1353764 | 0.72 | HTT (0.56) | HDAC4HTTRAB9AMAPTNPC1 | |
| SCHEMBL12422701 | 0.72 | HTT (0.59) | HDAC4HTTRAB9AMAPTNPC1 | |
| SCHEMBL30504112 | 0.71 | MAOA (0.41) | HDAC4TSHRCYP2C9CYP1A2CYP2C19 | |
| SCHEMBL18725064 | 0.70 | HTT (0.58) | HDAC4HTTRAB9AMAPTNPC1 | |
| SCHEMBL19366231 | 0.69 | HDAC4 (0.61) | HDAC4HTTRAB9AMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765054-B2 | Histone deacetylase inhibitors and compositions and methods of use thereof | CHDI FOUNDATION, INC. (US) | 2017-09-19 | — | — | US | disclosed |