Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
| ▸ | BRAF | P15056 | 3/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 2/20 | 0.31 |
| ▸ | CSF1R | P07333 | 2/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.31 |
| ▸ | KIT | P10721 | 2/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.31 |
| ▸ | FLT1 | P17948 | 2/20 | 0.31 |
| ▸ | KDR | P35968 | 2/20 | 0.31 |
| ▸ | FLT3 | P36888 | 2/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.31 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.31 |
| ▸ | PLK4 | O00444 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26876461 | 0.78 | JAK2 (0.45) | JAK2BRD4CYP2C19CYP3A4CLK1 | |
| SCHEMBL14194694 | 0.78 | BRD4 (0.45) | JAK2BRD4CYP2C19CYP3A4CYP2D6 | |
| SCHEMBL18211756 | 0.77 | MAP3K11 (0.47) | JAK2BRD4CYP2C19CYP3A4BRAF | |
| SCHEMBL26696343 | 0.77 | JAK2 (0.44) | JAK2BRD4CYP2C19CYP3A4BRAF | |
| SCHEMBL19287905 | 0.75 | BRD4 (0.43) | JAK2BRD4CYP2C19CYP3A4BRAF | |
| SCHEMBL21738169 | 0.73 | JAK2 (0.50) | JAK2CYP2C19CYP3A4BRAFCYP2D6 | |
| SCHEMBL26696371 | 0.72 | DYRK1A (0.45) | JAK2BRD4CYP3A4 | |
| SCHEMBL21872980 | 0.72 | JAK2 (0.41) | JAK2BRD4CYP2C19CYP3A4BRAF | |
| SCHEMBL19829825 | 0.70 | BRD4 (0.40) | JAK2BRD4CYP2C19CYP3A4CYP2D6 | |
| Methylene Chloride SCHEMBL27892257 | 0.70 | CYP2C9 (0.54) | JAK2CYP2C19CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2560972-B1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC (US) | 2017-09-20 | — | — | EP | disclosed |