Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.39 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.39 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 2/20 | 0.31 |
| ▸ | CSF1R | P07333 | 2/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.31 |
| ▸ | KIT | P10721 | 2/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.31 |
| ▸ | FLT1 | P17948 | 2/20 | 0.31 |
| ▸ | KDR | P35968 | 2/20 | 0.31 |
| ▸ | FLT3 | P36888 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19287905 | 0.88 | BRD4 (0.43) | MAP3K11BRD4JAK2BRAFCYP3A4 | |
| SCHEMBL14194694 | 0.82 | BRD4 (0.45) | MAP3K11BRD4JAK2TDO2CYP3A4 | |
| SCHEMBL18211757 | 0.82 | BRD4 (0.39) | MAP3K11BRD4JAK2BRAFCYP2C19 | |
| SCHEMBL26876461 | 0.80 | JAK2 (0.45) | BRD4JAK2CYP3A4CYP2C19CLK1 | |
| SCHEMBL26696343 | 0.79 | JAK2 (0.44) | BRD4JAK2BRAFCYP3A4CYP2C19 | |
| SCHEMBL19366334 | 0.77 | JAK2 (0.39) | BRD4JAK2BRAFCYP3A4CYP2C19 | |
| SCHEMBL26696371 | 0.74 | DYRK1A (0.45) | BRD4JAK2CYP3A4 | |
| SCHEMBL12252458 | 0.74 | CYP2C9 (0.49) | MAP3K11BRD4JAK2PRKAG1PRKAA1 | |
| SCHEMBL19829825 | 0.74 | BRD4 (0.40) | BRD4JAK2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL3821880 | 0.73 | CYP2C9 (0.42) | BRD4PRKAG1PRKAA1PRKAB1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10040792-B2 | Synthesis of a compound that modulates kinases | PLEXXIKON INC. (US) | 2018-08-07 | — | — | US | disclosed |
| US-20170334909-A1 | SYNTHESIS OF A COMPOUND THAT MODULATES KINASES | DAIICHI SANKYO, INC. | 2017-11-23 | — | — | US | disclosed |
| US-9745298-B2 | Synthesis of a compound that modulates kinases | PLEXXIKON INC. (US) | 2017-08-29 | — | — | US | disclosed |
| US-20160326169-A1 | SYNTHESIS OF A COMPOUND THAT MODULATES KINASES | DAIICHI SANKYO, INC. | 2016-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10040792-B2 | Synthesis of a compound that modulates kinases | FLT3, KIT, MAP3K1 | MAP3K11 9/4885BRD4 1088/4885JAK2 25/4885 |
| US-20170334909-A1 | SYNTHESIS OF A COMPOUND THAT MODULATES KINASES | FLT3, KIT, MAP3K1 | MAP3K11 9/4885BRD4 1088/4885JAK2 25/4885 |
| US-20160326169-A1 | SYNTHESIS OF A COMPOUND THAT MODULATES KINASES | FLT3, KIT, MAP3K1 | MAP3K11 9/4885BRD4 1088/4885JAK2 25/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.