Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | MAP2K1 | Q02750 | 16/20 | 0.53 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.47 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.47 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.47 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.47 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | NQO2 | P16083 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15131425 | 0.90 | MEN1 (0.60) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL19366741 | 0.87 | MAP2K1 (0.56) | MAP2K1MAP2K2CSNK2A2ABCB11NQO2 | |
| SCHEMBL5989891 | 0.86 | MEN1 (0.71) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL19367452 | 0.86 | MEN1 (0.41) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL19367201 | 0.84 | MAP2K1 (0.55) | MAP2K1MAP2K2ABCB11NQO2 | |
| SCHEMBL19366568 | 0.83 | MAP2K1 (0.44) | MAP2K1MAP2K2ABCB11NQO2PIM1 | |
| SCHEMBL15131337 | 0.83 | MAP2K1 (0.54) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL19366614 | 0.83 | MEN1 (0.54) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL19366561 | 0.82 | MAP2K1 (0.53) | MAP2K1MAP2K2ABCB11NQO2CSF1R | |
| SCHEMBL19367210 | 0.81 | MEN1 (0.54) | MEN1KMT2ATDP1MAP2K1MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9937158-B2 | Benzoheterocyclic compounds and use thereof | SHANGHAI KECHOW PHARMA, INC. (CN) | 2018-04-10 | — | — | US | disclosed |
| EP-2804855-B1 | BENZOHETEROCYCLIC COMPOUNDS AND USE THEREOF | SHANGHAI KECHOW PHARMA INC (CN) | 2017-09-20 | — | — | EP | disclosed |