Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.71 |
| ▸ | MAP2K1 | Q02750 | 18/20 | 0.54 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.54 |
| ▸ | RAF1 | P04049 | 1/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.54 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.54 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.54 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.54 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.54 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.54 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.54 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15131425 | 0.92 | MEN1 (0.60) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL5989361 | 0.87 | MEN1 (0.71) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL19367204 | 0.86 | MEN1 (0.54) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL5989568 | 0.85 | MEN1 (0.73) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL5988265 | 0.85 | MEN1 (0.73) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL5989886 | 0.84 | MEN1 (0.64) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL3862123 | 0.83 | MEN1 (0.71) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL5988785 | 0.83 | MEN1 (0.71) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL5990580 | 0.83 | MEN1 (0.61) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL1801637 | 0.83 | MEN1 (1.00) | MEN1KMT2ATDP1MAP2K1MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7030119-B1 | Method for treating chronic pain using MEK inhibitors | WARNER-LAMBERT COMPANY (US) | 2006-04-18 | — | — | US | disclosed |
| EP-1144385-B1 | BENZOHETEROCYCLES AND THEIR USE AS MEK INHIBITORS | WARNER LAMBERT CO (US) | 2005-08-17 | — | — | EP | disclosed |
| US-6469004-B1 | Benzoheterocycles and their uses as MEK inhibitors | WARNER-LAMBERT COMPANY | 2002-10-22 | — | — | US | disclosed |
| EP-1202731-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2002-05-08 | — | — | EP | disclosed |
| EP-1144385-A1 | BENZOHETEROCYCLES AND THEIR USE AS MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2001005390-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-01-25 | — | — | WO | disclosed |
| WO-2000042022-A1 | BENZOHETEROCYCLES AND THEIR USE AS MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2000-07-20 | — | — | WO | disclosed |